From genes to brain: Schizophrenia untangled

From genes to brain: Schizophrenia untangled.

An early defect in a critical neurological pathway may be responsible for the onset of schizophrenia later in life.

The genomic pathway, called the Integrative Nuclear FGFR 1 Signaling (INFS), is a central intersection point for multiple pathways of as many as 160 different genes believed to be involved in the disorder.

“We believe this is the first model that explains schizophrenia from genes to development to brain structure and finally to behavior,” says lead author Michal Stachowiak, professor in the Department of Pathology and Anatomical Sciences at the University at Buffalo.