ApoE Is an ideal target for halting progression of Alzheimer’s disease

ApoE Is an ideal target for halting progression of Alzheimer’s disease.

Despite researchers’ best efforts, no drug exists that can slow, halt or reverse the onslaught of Alzheimer’s disease. A progressive and fatal neurodegenerative disorder, Alzheimer’s has stolen the memories and livelihoods of millions – leaving patients and their families struggling to cope with the disease’s devastating consequences. But today, scientists at the Gladstone Institutes propose a new research avenue that has the potential to change all that.

In the latest issue of the journal Neuron, available today online, Gladstone Investigators Robert Mahley, MD, PhD, and Yadong Huang, MD, PhD, describe – at the molecular and cellular level – the process by which an important protein, known as apoE4, promotes the development of Alzheimer’s. In so doing, they recommend a renewed focus on a strategy that could fundamentally change the course of the disease’s progression.